Endocrine Abstracts

This work aimed to evaluate pituitary–adrenal axis and tissue metabolism of cortisol in patients with long standing type one diabetes.Fifty patients with diabetes type 1 were investigated; age 38±10 years (mean±S.D.), age at diagnosis 25.5±10 years, disease duration 15±8 years, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%. Control group consisted of 40 healthy volunteers.The study...

Aim: To study the insulin sensitivity and secretion in women with polycystic ovary syndrome (PCOS).Subjects and methods: Thirty-eight women with PCOS (age 26.1±4.1 years, BMI 20.9±2.0 kg/m2) and 81 control healthy women (age 25.8±5.2 years, BMI 21.1±2.3 kg/m2) underwent oral glucose tolerance test (OGTT). Insulin resistance was evaluated as oral glucose index (OGIS); Matsuda and HOMA-IR, insulin secretion was cal...

Introduction: The influence of steroid hormones on food intake is well described. However, there are only a few studies on the effect of food intake on steroid levels.Methods: The study involved eight non-smoker women (average age 29.48±2.99 years; average BMI 21.3±1.3 kg/m2); they did not use any kind of medication affecting steroidogenesis. We analysed the influence of four various stimuli on the levels of steroid hormones and mela...

Background of the study: There is lack of data in the Czech Republic on iodine status in patients suffering from diabetes mellitus type 1 (DM1) considered to be at risk of iodine deficiency.Subjects and methods: A total of 54 males and 51 females ‒ median (25th, 75th percentile): age (years) 42 (31, 55); BMI 25.9 (23.3, 29.7); HbA1c (mmol/mol) 61 (51.2, 71.0) treated for DM1 were included in this cross–sectional study. In addition to iodine s...

Introduction: The dependence on tobacco, diagnosis F 17, is an independent condition in the International classification of diseases and presents one of the most widespread addictions. Chronic smoking can cause impairment of fertility in both sexes. However, only a small number of studies were dedicated to the influence of smoking on levels of steroid hormones and their neuroactive metabolites. Neuroactive steroids modulate the effects of tobacco on central nervous system, and...

Introduction: Cigarette smoking is one of the most serious substance abuse problems. It is generally accepted that nicotine and other chemicals in tobacco smoke alter endocrine function in women, induce changes in female hormonal balance and likely contributes to reported associations of smoking with adverse reproductive outcomes, including menstrual dysfunction, infertility, and earlier menopause. Studies on the effects of smoking and smoking cessation on female sex hormones ...

The aim of the study was to obtain the basic data about adrenomedullin after 1 μg ACTH stimulation.Adrenomedullin has direct effect on adrenal cortex secretion, therefore we studied the changes of its concentrations during ACTH stimulation in diabetic patients suspected of hypocorticalism.Thirty-two diabetics type 1 (DM1) were investigated; 16 with and 16 without autoimmune thyroditis (AIT); age 44±10 years (mean±<sm...

Introduction: 7-hydroxyl DHEA derivatives are labelled as natural anti-glucocorticoid and neuroprotective substances. Their impact on the production of cytokines, their activation of apoptosis, influence on the migration of macrophages to peripheral tissue, their possible effect on angiogenesis, effect on inflammatory mediators (arachidonic acid metabolites) and their role in the mechanism of oxidative stress have been described.Methods: In our study we ...

The aim of the study was to obtain data about peripheral metabolism of cortisol.We compared diabetics with low response (LR), and with normal response (NR) during low dose ACTH test, and a control group (C).Twelve diabetics were investigated; LR (n=6), NR (n=6), age 44±10 year (mean±S.D.), age at diagnosis of DM1 28.5±10 year, disease duration 15±8 year, BMI 24.5±2.7 kg/cm2...

Melatonin has a key role in circadian timing system. At present, many other functions of melatonin are known. It shows a remarkable functional versatility exhibiting antioxidant (direct free radical scavenging and indirect antioxidant activities), oncostatic, anti-aging, immunomodulatory properties and many other functions. In addition to pineal gland, gastrointestinal tract is the second biggest source of melatonin. Question remains whether changes in endogenous melatonin may...